I stayed in a lovely apartment near Ca'D'oro. To be honest, Venice is small enough that you can walk anywhere very easily, or get a boat. It might be a little noisy, but I wouldn't worry about whether or not you feel safe. It's actually a very safe city (though a lot of pickpocketing, so be careful!). I wandered around it on my own late at night without ever feeling threatened.
I totally recommend taking a trip out to the other islands - I love San Michele (the island graveyard) but I can see how others might find it morbid.
Wherever possible try to find places that look like the locals are eating in them - you won't regret it. There's a lovely one in the backstreets of Ca'D'oro, but I couldn't direct you to it.
Best advice - get lost. Find things that aren't in a guide book. I hope you enjoy yourself and love it as much as I did.
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I totally recommend taking a trip out to the other islands - I love San Michele (the island graveyard) but I can see how others might find it morbid.
Wherever possible try to find places that look like the locals are eating in them - you won't regret it. There's a lovely one in the backstreets of Ca'D'oro, but I couldn't direct you to it.
Best advice - get lost. Find things that aren't in a guide book. I hope you enjoy yourself and love it as much as I did.